Mastering MRD for Prognosis and Treatment in ALL

Estimated Time
1.00 hour

Release Date
Oct 14, 2022

Expiration Date
Oct 29, 2023


Acute lymphoblastic leukemia (ALL) is the first hematologic neoplasm for which assessment of early response to therapy using measurable residual disease (MRD) has proven to be a fundamental tool for guiding therapy. It should be a key component in individualizing care to improve outcomes for patients. But MRD is a time point-dependent variable, with different time points signifying different prognosis for relapse. And MRD testing methods are variable across clinical practices, and it can be challenging to select the appropriate combination and sequence of therapy. Consequently, not all patients are provided with uniform care.

During Mastering MRD for Prognosis and Treatment in ALL, experts will discuss conducting MRD testing for patients with ALL according to the guideline-recommended schedule; evaluating the specimens needed for, and the pros and cons of, various methods for assessing MRD; predicting the risk of relapse based on MRD test results; and individualizing treatment based on MRD status to ensure patients at higher risk of relapse receive appropriate risk-adapted therapy.

This taped Satellite Symposium was derived from the Society of Hematologic Oncology 2022 Annual Meeting.


Accreditation and Disclosure Information

This CE activity is intended for hematologic oncology clinicians, nurses, and pharmacists who provide care for individuals with acute lymphoblastic leukemia (ALL).

After completing this CE activity, the participant should be better able to:

  • Conduct MRD testing according to the guideline-recommended schedule
  • Evaluate the specimens needed for, and the pros and cons of, various methods of assessing MRD
  • Predict the risk of relapse based on MRD test results
  • Individualize treatment based on MRD status to ensure patients at higher risk of relapse receive appropriate risk-adapted therapy


  • Welcome, introductions, overview
  • Timing of MRD testing
  • MRD testing methods
  • Interpreting results of MRD tests
  • Using results to guide treatment
  • Summary of key points, post-test, evaluation, and final Q&A


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Physician Continuing Medical Education
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MOC Statement


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Universal Activity Number: JA0007322-0000-22-112-H01-P
Type of Activity: Knowledge

This activity is supported by educational funding provided by Amgen.

Medical Learning Institute, Inc., is committed to providing high quality continuing education to healthcare professionals, as individuals and teams, with a protected space to learn, teach, and engage in scientific discourse free from influence from ineligible companies that may have an incentive to insert commercial bias into education. To that end, MLI requires faculty, presenters, planners, staff, and other individuals who are in a position to control the content of this CE activity to disclose all financial relationships they have had in the past 24 months with ineligible companies as defined by the ACCME, as related to the content of this CE activity, regardless of the amount or their view of the relevance to the education. All identified COI will be thoroughly vetted and mitigated according to MLI policy. These disclosures will be provided to learners prior to the start of the CE activity.

Jae H. Park, MD
Associate Attending Physician
Acting Chief, Cellular Therapeutic Service
Memorial Sloan Kettering Cancer Center,
New York, NY

Advisory Board/Consultant: Amgen, Allogene, Affyimmune, Artiva, Autolus, Bright Pharma, Bristol Myers Squibb, Curocell, GlaxoSmithKline, Incyte, Intellia, Kite Pharma, Kura Oncology, Minerva, Novartis, Pfizer, and Servier.
Research Grant: Fate Therapeutics, Genentech, and Takeda.

Rashmi Kanagal Shamanna, MD
Associate Professor, Department of Hematopathology
Director, Molecular Diagnostic Laboratory – Microarray
The University of Texas MD Anderson Cancer Center
Houston, TX

Advisory Board/Consultant: Amgen, Inc.
Speakers’ Bureau: Amgen, Inc.
The following relationships have ended within the last 24 months:
Advisory Board/Consultant: Aptitude Health and Novartis
Speakers’ Bureau: Physicians’ Education Resource

All of the relevant financial relationships of individuals for this activity have been mitigated.

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